xPerts64 (a Microsoft x64 blog) has a hint on how to Disable UAC Prompt for a Single Application. Genius! Still a bit overly-complex for a normal person, but handy I suppose if you have something you use often that requires UAC (for me, BF2142 and Quickbooks) that you know is safe.

I wonder why a) Microsoft didn't put something like this into Vista to begin with (possibly to "force" application developers to change their apps to be UAC compliant) and b) if this could be scripted out by malware authors.